It runs only one algorithm at a time and while most algorithms have only one effect, there are a few that have multiple effects. E.g. pitch+fuzz, tremelo+reverb, echo+reverb+modulation. If you have specific combinations you are looking for, I suggest looking at their algorithm list to see if it is covered. I have a stand alone delay and my amp supplies a good bias trem and my always on reverb, so it is not an issue for me. It also has some nice routing functions. It can be wet only if you run a parallel dry signal. Also has stereo ins and outs. If you don't use stereo, then you can use the extra loop so that the H9 can be in 2 different positions on your board, assignable to each preset. E.g. when you use fuzz or octave, it can be earlier in the chain. If using mods or delay, that can be set to the other loop that is later in the chain.