Straight in ... in the order Booster - Overdrive - Time Based Other - Delay - Reverb. Time based other may also be placed elsewhere, depends on the actual outcome, trial, error. Reverb (nearly) always is last. At home, when practicing, I usually have a volume pedal after reverb, so I can step it silent in case the doorbell indicates I might have a reason to go to, say, the door. My amp does have a loop, but I compared this and didn't hear any difference at home volume, it's just more cablery necessary then.