Lately, I've been pondering left-handed guitars. I'm right-handed, but between pronator teres syndrome in my right forearm (similar to carpal tunnel, but the pinch point is between branches of the pronator teres muscle) and arthritis in my left thumb, playing backwards is starting to seem like an option. Decades ago, I worked with a woman who was right-handed but played lefty because of an industrial accident, and of course many southpaws (including my father) play right handed. Granted, as lefties already know, the selection of instruments is far more limited, and at 57, learning all over again is daunting (though at least some knowledge transfers). I doubt if I would try to switch completely. I'd probably go for ambidextrous playing to reduce the wear and tear. And yeah, after I had to quit playing completely for several years because of ignoring the pronator teres pain until I couldn't, I pay a lot of attention to posture and what my body is telling me.