I haven't often run a compressor much except for bass. So I'm just pulling it unless I'm recording. Will try switching it around in the chain next. As far as the Brain ... it's getting velcro'd in this weekend. Normal always on and ABBY with bass all the way down for lead boost. With the Brain on, my SC2 in crunch mode and gain rolled off, a vintage Strat neck pickup it's SRV city. And of course it's perfect with the Gretsch for the one Stray Cats tune and one original. To be honest ... I was a little skeptical at first. But it really is different from the other pres I've tried. If I had a pedal with the Brain on one side and a 'grit' on the other with it's own level conttol I could die happy.