You might also consider acupuncture. I was an acupuncture skeptic until my wife, an MD, told me that Harvard Medical School was offering a science-based program in medical acupuncture. She took the course, brought the practice back to her chronic pain patients, and saw amazing results. It's starting to gain more acceptance in mainstream medicine now. If you do try it, I'd suggest looking for an MD with training in medical acupuncture—though who knows; you might find good results with a traditional practitioner. I'd also second @drmilktruck's recommendation to see a physiotherapist. They may be able to suggest stretches, strengthening exercises, and different hand positions or neck shapes to minimize the problem. My mom is a retired physiotherapist; she gave me some good advice on playing through a chronic wrist injury. As @RG7X suggested, a smaller fretboard radius is also worth considering. When my wrist flares up, I put down my 15" radius Hagstrom and pick up my 10" radius PRS SE 245. The wrist has been pretty good lately, but if it ever gets really bad, I'll be shopping for a 7.25" radius Tele.