If you have an iPad or iPhone with a mini 3.5mm jack, then you should be able to hook up a mono microphone and a stereo headphone using a Tip-Ring-Ring-Sleeve (TRRS) adapter, for example: https://www.amazon.com/Kingtop-Adapter-Tablet-Headsets-Version/dp/B01I3A47I4/ If your device has a Lightning port, then you need the Apple adapter also: https://www.apple.com/shop/product/MMX62AM/A/lightning-to-35-mm-headphone-jack-adapter or the combo charge/audio adapter https://www.amazon.com/Certified-Lightning-Headphone-Earphone-Compatible/dp/B07ZC24X51/ So, if basically you would have a mono input and a stereo output through those 3.5mm (1/8" mini jacks) and with appropriate adapters you can go from guitar to iPhone and from iPhone to amp (or stereo inputs on a pedal board or PA). I found that the levels on my Tele and Gretsch (Blacktop Filtertrons on Electromatic) are too hot for the audio input on the iPhone or iPad, so I have to turn my guitar volume down to about 50%-75% or it will saturate and cut out, kind of like a noise gate but with a ceiling instead of a floor. Here is a photo of the cables I used to go from guitar to amp, via the iPhone/iPad (either a mini jack or Lightning port) You can use a regular 1/4" mono guitar cable in place of the U2 wireless. The first 1/4" to 1/8" adapter only needs to be mono, but I have a stereo adapter shown here that plugs the guitar input into the mic input on the TRRS splitter. I have a longer 1/8" stereo cable to from the headphone side of the TRRS splitter and then that goes into a stereo 1/8" to 1/4" adapter. Then you can split the left-right stereo channels with a 1/4" jack splitter and just use one or both into a PA or stereo pedal, or just one into your amp. Of course, you could just use a set of headphones or the iPhone built-in speakers if you want. With that TRRS adapter you might get some cross talk between the mic and headphone, since they share a sleeve for common ground, but I have not noticed that. So, without any special audio interface, just these cables and adapters you can tap into GarageBand on your iPhone or iPad and try out those amp and pedal models. They also have additional track effects that includes more advanced settings for compression, reverb, and delay beyond the included pedals. I have just started playing around with it. Kind of fun for messing around with at home, not sure if I have enough confidence in my ability to play live with it at this point, it is really oriented more for recording than playing live, but you probably could get the hang of it, if you have a good sturdy stand where you can operate the iPad or iPhone. An external audio interface (iRig, etc) may offer more features and level settings, but I think all you really need is that TRRS adpater cable to get the mic/headphone jacks.