Thanks, Synchro. Based on the posted specs, it seems like the body & neck of these new models have cosmetic upgrades only. In terms of structural sonic design, they aren't significantly different from the 5120/22. (I did read a user comment that suggests the top arch increases lower down on the body compared with the old series, but I don't know how that would effect sound.) If I didn't already have a 5122, I would buy a 5422. But the pups seem to be the only significant sonic upgrade. Hard to know without playing one though!
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